Well, you haven't given us much to go on.

I would suspect you have a problem with video drivers. Update them and
reduce hardware acceleration at control panel, display, settings, advanced,
performance.

I agree with Sandi.

You probably need new video drivers.  Check the site for your video board
manufacturer.  Meanwhile you can do the following:
1.  Use the default mouse pointers.
2.  Turn down your color depth.  (Right click the desktop and choose
Properties | Appearance | Settings)  Some people find that increasing color
depth helps.
3.  Turn down your graphics hardware acceleration.  (For Win 98, Start |
Settings | Control Panel | System | Performance | Graphics button)  You will
see little, if any, performance degradation.
4.  Turn off your desktop wallpaper.

If these make the problem go away you need new video drivers.

If you have an ATI video board, try adding these lines to System.ini

[display]
DevBMP=0      <--- That's a zero

BTW, that's zero-E, not Oh-E.  It is not referring to Outlook Express.