If script debugging is not installed, then it doesn't matter
whether the box is checked or not.

However, if script debugging IS installed,
which is seems t be in your case,
then it does matter whether the box is checked or not.

As you wish to "Disable script debugging",
you need to check the box.

Conversely, as you do NOT want notifications,
leave unchecked the option titled
"Display a notification about every script error"

If you are comfortable editing the Registry, read this
Microsoft Knowledge Base Article - 221438
OFF2000: Files Whose Name Begins with "fff" Appear in Windows Folder
http://support.microsoft.com/default.aspx?scid=kb;en-us;221438

If not, run MSCONFIG, click the Startup tab,
and uncheck MDM.EXE to prevent it from running,
as a workaround until someone can provide you
with a REG file which will update your Registry for you.

You must check the first. Only the second must be unchecked. Well, if
that doesn't do it, then... What is the precise wording of the error
message?

May as well clean up your Startup Group...

First pick one of these to identify what loads at boot. Next, see
whether there is an option in it's menus to disable it from starting up.
If you really want to rid yourself of it on a more permanent basis, then
look for it in "Control Panel, Add/Remove Programs". However, it isn't
often easy to know what is what in there. One of these URL's may say.
Only last, go to StartUpCop.

http://support.microsoft.com/default.aspx?scid=KB;EN-US;q137367
Startup Items
http://support.microsoft.com/support/kb/articles/q179/3/65.asp
Startup Group
http://support.microsoft.com/default.aspx?scid=kb;en-us;Q282107 Startup
http://aumha.org/a/loads.htm
http://users.westelcom.com/rogersr/clean.htm
http://web.ukonline.co.uk/sheppard.p/startup.htm
http://www.answersthatwork.com/Tasklist_pages/tasklist_a.htm
http://www.djbdesigns.com/wtvzone/startup.html
http://www.mlin.net/StartupCPL.shtml
http://www.pacs-portal.co.uk/startup_content.htm
http://www.sysinfo.org/startupinfo.php
http://www2.cajun.net/~theriots/blk/start.htm
http://www2.whidbey.com/djdenham/Uncheck.htm
http://www.3feetunder.com/krick/startlist.htm

http://www.pcmag.com/ 's StartUpCop has "undo", and it is more than a
combination of "START, Run, MSInfo32, Software Environment, Startup
Programs" and "START, Run, MSConfig, Startup tab". It can even do a
permanent delete. Of course, first see whether the app has an option in
it's own menus to remove itself from the Startup Group. This is
configurable, and one may maintain multiple configurations.

Update definitions & check for viruses, and
http://aumha.org/secure.htm
http://mvps.org/winhelp2002/unwanted.htm
http://www.mvps.org/inetexplorer/Darnit.htm#tshoot
http://patrick.kolla.de/spybotsd.html SpyBot- Search & Destroy. SpyBot
is gabby in it's "Checks" & "Fixes" logs. Turn them off in "Settings".
http://www.lavasoftusa.com/ AdAware
http://www.lavasoftusa.de/ Also AdAware
http://www.merijn.org/cwschronicles.html CoolWebSearch Chronicles
http://www.merijn.org/files/cwshredder.zip & CWShredder
http://www.merijn.org/files/hijackthis.zip Finally, Hijack This
(Better be careful with HijackThis.)

Help!!!

If all fails, then:

Microsoft's Scripting download
Get the latest. Two download versions are available for Windows Script 5.6.
The first version requires Windows 2000, XP; the second version requires
Microsoft Windows 98, Millenium Edition (Me), or NT 4.0.
Choose the download appropriate for your operating system.
http://msdn.microsoft.com/library/default.asp?url=/downloads/list/webdev.asp

Help!!!