Probably not. The UART chip in the serial port has an upper speed limit and
AFAIK that's about it for most of them.

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Richard G. Harper [MVP Shell/User] rgharper@gmail.com
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> I have a direct cable (back-to-back) connection between COM ports
> between a desktop and laptop machines both running XP Home. This runs fine
> at 115200 bps. I was wondering if there was any way of speeding this up?
> There was a way of changing normal(!) modem speeds to 921600bps at one
> time or so I believe.